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Cayman Gefitinib
List Price $270.00 Your Price $270.00
Cayman Gefitinib - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-13166-1
MFG.PART: 13166-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Gefitinib is an EGFR inhibitor (IC50s = 0.023-0.079 µM). It inhibits colony formation of GEO colon, ZR-75-1 and MCF-10A breast, and OVCAR-3 ovarian cancer cell lines in soft agar assays (IC50s = 0.2-0.4 µM). Gefitinib (0.1 to 1 µM) induces apoptosis and inhibits EGFR autophosphorylation in the same cells. In vivo, gefitinib (1.25, 2.5, and 5 mg/kg) reduces tumor volume and increases survival in a GEO mouse xenograft model. Formulations containing gefitinib have been used in the treatment of non-small cell lung cancer (NSCLC).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-
CAS Number
184475-35-2
Synonyms
- ZD 1839
Molecular Formula
C22H24ClFN4O3
Formula Weight
446.9
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/mL
- DMSO: 20 mg/mL
- DMSO:PBS(pH7.2) (1:1): 0.5 mg/mL
- Ethanol: 0.3 mg/mL
λmax
205, 226, 250, 332 nm
SMILES
COC1=CC2=C(C(NC3=CC=C(F)C(Cl)=C3)=NC=N2)C=C1OCCCN4CCOCC4
InChi Code
InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
InChi Key
XGALLCVXEZPNRQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-13166-1 |
|---|---|
| Supplier Part Number | 13166-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 184475-35-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |