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Cayman NSC 23766 (hydrochloride)
List Price $262.00 Your Price $262.00
Cayman NSC 23766 (hydrochloride) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-13196-25
MFG.PART: 13196-25
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Rac1 is a GTPase that is involved in the regulation of the cell cycle, cell-cell adhesion, motility, and differentiation.1 Rac1 is activated by its interaction with specific guanine nucleotide exchange factors (GEFs). NSC 23766 is a cell-permeable, reversible inhibitor of Rac1 activation by the Rac-specific GEFs TrioN and Tiam 1 (IC50 = 50 μM).2 It has no effect on the closely related GTPases, Cdc42 and RhoA. NSC 23766 has been used to investigate the role of Rac1 in such diverse cellular functions as stem cell mobilization, epithelial cell migration, angiogenesis, leukemia cell migration and growth, and gene expression.3,4,5,6,7
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N6-[2-[[4-
CAS Number
1177865-17-6
Molecular Formula
C24H35N7 • 3HCl
Formula Weight
531.0
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 2 mg/mL
- DMSO: 20 mg/mL
- Ethanol: 3 mg/mL
- PBS (pH 7.2): 10 mg/mL
λmax
219, 288, 324 nm
SMILES
CC1=NC2=C(C(N)=C1)C=C(NC3=NC(NC(C)CCCN(CC)CC)=NC(C)=C3)C=C2
InChi Code
InChI=1S/C24H35N7/c1-6-31(7-2)12-8-9-16(3)27-24-28-18(5)14-23(30-24)29-19-10-11-22-20(15-19)21(25)13-17(4)26-22/h10-11,13-16H,6-9,12H2,1-5H3,(H2,25,26)(H2,27,28,29,30)
InChi Key
DEFBCZWQLILOJF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-13196-25 |
|---|---|
| Supplier Part Number | 13196-25 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1177865-17-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |