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Cayman AA-861
List Price $183.00 Your Price $183.00
Cayman AA-861 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-13263-500
MFG.PART: 13263-500
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
AA-861 is an inhibitor of 5-lipoxygenase (5-LO; IC50 = 0.8 µM).1 It is greater than 100-fold selective for 5-LO over 12-LO and cyclooxygenase (COX). AA-861 inhibits the production of 5-HETE and leukotriene B4 (LTB4; Item Nos. 20110 | 10007240) induced by A23187 (Item No. 22030) with IC50 values of 0.03 and 0.08 µM, respectively, in isolated rat peritoneal macrophages.2 It reduces paw edema, pleurisy, and cell infiltration induced by carrageenan in rats when administered at a dose of 80 mg/kg. AA-861 (20 mg/kg) reduces ovalbumin-induced bronchoconstriction in an ovalbumin-sensitized guinea pig model of experimental allergic asthma.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-(12-hydroxy-
CAS Number
80809-81-0
Synonyms
- A-61589
- Docebenone
Molecular Formula
C21H26O3
Formula Weight
326.4
Purity
≥95%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMSO: 250 mg/mL, sonicated
SMILES
CC1=C(C)C(C(CCCCC#CCCCC#CCO)=C(C)C1=O)=O
InChi Code
InChI=1S/C21H26O3/c1-16-17(2)21(24)19(18(3)20(16)23)14-12-10-8-6-4-5-7-9-11-13-15-22/h22H,5,7-10,12,14-15H2,1-3H3
InChi Key
WDEABJKSGGRCQA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-13263-500 |
|---|---|
| Supplier Part Number | 13263-500 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 80809-81-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |