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Cayman NU 7026
List Price $168.00 Your Price $168.00
Cayman NU 7026 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-13308-10
MFG.PART: 13308-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
DNA-dependent protein kinase (DNA-PK) binds to strand breaks produced during normal cellular processes or in response to genotoxic stresses, such as ionizing radiation, targeting substrates that facilitate DNA repair. NU 7026 is a cell-permeable, potent, specific, and ATP-competitive inhibitor of DNA-PK (IC50 = 230 nM). It poorly inhibits phosphioinositide 3 kinase (IC50 = 13 μM) and is inactive against ataxia telangiectasia mutated kinase, ATR, and poly (ADP-ribose) polymerase. NU 7026 impairs cellular DNA double strand break repair and decreases survival in cells exposed to ionizing radiation. It also potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia. For example, it potentiates the growth inhibitory effects of mitoxantrone in K562 cells more than 10-
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-
CAS Number
154447-35-5
Synonyms
- DNA-
PK Inhibitor II - LY293646
Molecular Formula
C17H15NO3
Formula Weight
281.3
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 0.15 mg/mL
λmax
219, 255, 315 nm
SMILES
O=C1C=C(N2CCOCC2)OC3=C4C=CC=CC4=CC=C31
InChi Code
InChI=1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6,11H,7-10H2
InChi Key
KKTZALUTXUZPSN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-13308-10 |
|---|---|
| Supplier Part Number | 13308-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 154447-35-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |