Cayman NU 7026

DNA-dependent protein kinase (DNA-PK) binds to strand breaks produced during normal cellular processes or in response to genotoxic stresses, such as ionizing radiation, targeting substrates that facilitate DNA repair. NU 7026 is a cell-permeable, potent, specific, and ATP-competitive inhibitor of DNA-PK (IC₅₀ = 230 nM).¹ It poorly inhibits phosphioinositide 3 kinase (IC₅₀ = 13 μM) and is inactive against ataxia telangiectasia mutated kinase, ATR, and poly (ADP-ribose) polymerase.¹ NU 7026 impairs cellular DNA double strand break repair and decreases survival in cells exposed to ionizing radiation.¹ It also potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia. For example, it potentiates the growth inhibitory effects of mitoxantrone in K562 cells more than 10-fold.²

WARNING This product is not for human or veterinary use.