Cayman AM3102

Oleoyl ethanolamide (OEA) is an endogenous agonist for proliferator-activated receptor α (PPARα) that suppresses food intake, promotes lipolysis, and reduces weight gain in rodents. The biological effects of OEA are terminated by fatty-acid amide hydrolase and N-acylethanolamine-hydrolyzing acid amidase. AM3102 is an OEA analog that stimulates PPARα transcriptional activity with an EC₅₀ value of 100 nM and prolongs feeding latency in rodents with an ED₅₀ value of 2.4 mg/kg. It is resistant to enzymatic hydrolysis and is as potent as OEA in enhancing transcriptional activity of PPARα and reducing food intake in free-feeding rats.^, AM3102 demonstrates weak affinity for the central cannabinoid (CB₁) and peripheral cannabinoid (CB₂) receptors with K_i values of 33 and 26 µM, respectively.

WARNING This product is not for human or veterinary use.