Cayman LH 21

LH 21 is a 1,2,4-triazole that acts as a cannabimimetic. It has a relatively low-affinity for the central cannabinoid (CB₁) receptor (K_i = 855 nM).¹ However, it interferes, at low nanomolar concentrations, with the action of the potent CB₁ agonist WIN 55,212-2 on murine vas deferens, suggesting that LH 21 acts as a silent CB₁ antagonist.¹ Consistent with this interpretation, LH 21 diminishes the in vivo effects of WIN 55,212-2 on standard CB tetrad responses in mice and reduces food intake and body weight gain in obese Zucker rats.^1,2,3 However, in CHO Cells overexpressing CB₁, LH 21 is able to elevate cAMP, suggesting that, in this model, it acts as an inverse agonist of CB₁.⁴ Furthermore, LH 21 suppresses food intake and body weight gain in both wild-type and CB₁ receptor knockout mice, indicating that this receptor is not necessary for these effects.⁴

WARNING This product is not for human or veterinary use.