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Cayman Trandolapril
List Price $228.00 Your Price $228.00
Cayman Trandolapril - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-13522-50
MFG.PART: 13522-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Trandolapril is a prodrug form of the angiotensin-converting enzyme (ACE) inhibitor trandolaprilat (Item No. 29577).1 Trandolapril is converted to trandolaprilat by carboxylesterase 1 (CES1) in human liver microsomes. It inhibits angiotensin I-induced pressor responses in rats and dogs (ID50s = 13.1 and 21.1 μg/kg, respectively) and potentiates the bradykinin-induced depressor response in rats (ED50 = 5.5 μg/kg).2 Trandolapril (0.1, 0.3, and 1 mg/kg) decreases systolic and diastolic arterial pressure in dogs. It decreases mean arterial pressure (MAP) and left ventricular end-diastolic pressure (LVEDP) in a rat model of heart failure induced by left coronary artery occlusion when administered at a dose of 3 mg/kg.3 Trandolapril (0.01 and 1 mg/kg) increases survival in stroke-prone spontaneously hypertensive rats fed a high-salt diet.4 Formulations containing trandolapril have been used in the treatment of hypertension.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(2S,3aR,7aS)-
CAS Number
87679-37-6
Synonyms
- RU-44570
Molecular Formula
C24H34N2O5
Formula Weight
430.5
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 15 mg/mL
- DMSO: 25 mg/mL
- Ethanol: 0.25 mg/mL
- PBS (pH 7.2): 1 mg/mL
SMILES
[H][C@@]12[C@](N(C([C@@H](N[C@H](C(OCC)=O)CCC3=CC=CC=C3)C)=O)[C@H](C(O)=O)C2)([H])CCCC1
InChi Code
InChI=1S/C24H34N2O5/c1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29/h4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29)/t16-,18+,19-,20-,21?/m0/s1
InChi Key
VXFJYXUZANRPDJ-GNFQLOHCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-13522-50 |
|---|---|
| Supplier Part Number | 13522-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 87679-37-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |