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Cayman AFP 07 (free acid)
List Price $251.00 Your Price $251.00
Cayman AFP 07 (free acid) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-13626-1
MFG.PART: 13626-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Prostaglandin I2 is an unstable prostanoid which, through the ‘I prostanoid’ (IP) receptor, inhibits platelet aggregation and promotes vasodilatation in pulmonary vascular beds. AFP 07 is a 7,7-difluoroprostacyclin derivative that acts as a selective and highly potent agonist for the IP receptor (Ki = 0.561 nM). AFP 07 shows weaker affinity for EP receptors, with Ki values of > 100 nM for EP1-3 and > 10 nM for EP4. In piglet and rabbit saphenous veins, which express both IP and EP4, the EP4 antagonist AH 23848 reduces AFP 07-mediated relaxation, suggesting that AFP 07 activates EP4 as well as IP, particularly when both receptors are present.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5Z-[(3aR,4R,
CAS Number
788799-13-3
Molecular Formula
C22H30F2O5
Formula Weight
412.5
Purity
≥98%
Formulation
A solution in methyl acetate
Solubility
- DMF: 30 mg/mL
- DMSO: 25 mg/mL
- Ethanol: 30 mg/mL
- PBS (pH 7.2): 1 mg/mL
SMILES
O[C@@H]([C@@H](C)CC#CCC)/C=C/[C@H]1[C@H](O)C[C@H]2[C@@H]1C(F)(F)/C(O2)=C\CCCC(O)=O
InChi Code
InChI=1S/C22H30F2O5/c1-3-4-5-8-14(2)16(25)12-11-15-17(26)13-18-21(15)22(23,24)19(29-18)9-6-7-10-20(27)28/h9,11-12,14-18,21,25-26H,3,6-8,10,13H2,1-2H3,(H,27,28)/b12-11+,19-9+/t14-,15-,16+,17+,18-,21+/m0/s1
InChi Key
PVHIRYQSPDZLLG-HBXWYSCUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 2 years
| SKU | CAYM-13626-1 |
|---|---|
| Supplier Part Number | 13626-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 788799-13-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |