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Cayman UNC0224
List Price $1,030.00 Your Price $1,030.00
Cayman UNC0224 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-13631-50
MFG.PART: 13631-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development.1,2,3 UNC0224 is a potent and selective G9a HMTase inhibitor, exhibiting an IC50 value of 15 nM.4 Isothermal titration calorimetry revealed UNC0224 binds to G9a with a Kd value of 29 nM. UNC0224 also inhibits GLP, a closely-related H3K9 HMTase, with assay-dependent IC50 values of 20-58 nM, but is more than 1,000-fold selective against SET7/9 (a H3K4 HMTase) and SET8 (a H4K20 HMTase).4
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
7-[3-(dimethyl
CAS Number
1197196-48-7
Molecular Formula
C26H43N7O2
Formula Weight
485.7
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 2.5 mg/mL
- DMSO: 2 mg/mL
- Ethanol: 15 mg/mL
- PBS (pH 7.2): 2.5 mg/mL
λmax
251, 346 nm
SMILES
COC1=CC2=C(NC3CCN(C)CC3)N=C(N4CCN(C)CCC4)N=C2C=C1OCCCN(C)C
InChi Code
InChI=1S/C26H43N7O2/c1-30(2)10-7-17-35-24-19-22-21(18-23(24)34-5)25(27-20-8-13-32(4)14-9-20)29-26(28-22)33-12-6-11-31(3)15-16-33/h18-20H,6-17H2,1-5H3,(H,27,28,29)
InChi Key
XIVUGRBSBIXXJE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-13631-50 |
|---|---|
| Supplier Part Number | 13631-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Netherlands |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1197196-48-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |