Cayman GANT 61

Hedgehog proteins, important regulators of development, bind the cell-surface protein Patched, allowing activation of Smoothened. In vertebrates, this ultimately leads to the activation of the zinc-finger transcription factors of the Gli family. Overactivation of this pathway contributes to certain cancers, including glioblastoma, for which the Gli proteins are named. GANT 61 is a Gli antagonist, inhibiting Gli1 activation of gene expression with an IC₅₀ value of 5 μM.¹ It does not affect signaling through NF-κB, glucocorticoid receptor, MAPK, HGF, C/EBPα, or HIF-1, supporting specificity for the Hedgehog pathway.¹ GANT 61 has been shown to inhibit the in vitro proliferation of PANC-1 and 22Rv1 cancer cells, which have elevated Gli1 levels, and prevent the development of 22Rv1 tumors in mice.¹

WARNING This product is not for human or veterinary use.