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Cayman NVP-231
List Price
$186.00
Your Price
$186.00
Cayman NVP-231 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-13858-10
MFG.PART:
13858-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
NVP-231 is a potent and reversible inhibitor of ceramide kinase (IC50 = 12 nM).1 It is selective for ceramide kinase over SPHK1, SPHK2, DAGKa, PI3Ka, PI4Kb, VPS34, GCS, SMS-1, and CERT (IC50s = >5 mm). NVP-231 inhibits formation of ceramide-1-phosphate (C1P; IC50 = 10 nM) and cell death in ceramide kinase overexpressing COS cells (COS-CerK). It also inhibits C1P formation and tube formation in murine dermal microvascular endothelial cells when used at a concentration of 100 nM.2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-
CAS Number
362003-83-6
Molecular Formula
C25H25N3O2S
Formula Weight
431.6
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 20 mg/mL
- DMSO: 12 mg/mL
- Ethanol: 1 mg/mL
λmax
224, 316 nm
SMILES
O=C(C1(C[C@@H](C2)C3)C[C@H]3CC2C1)NC4=CC(SC(NC(C5=CC=CC=C5)=O)=N6)=C6C=C4
InChi Code
InChI=1S/C25H25N3O2S/c29-22(18-4-2-1-3-5-18)28-24-27-20-7-6-19(11-21(20)31-24)26-23(30)25-12-15-8-16(13-25)10-17(9-15)14-25/h1-7,11,15-17H,8-10,12-14H2,(H,26,30)(H,27,28,29)/t15-,16-,17?,25?/m1/s1
InChi Key
MVSSJPGNLQPWSW-FGUCWDTJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-13858-10 |
|---|---|
| Supplier Part Number | 13858-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 362003-83-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |