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Cayman SR 9186
List Price $568.00 Your Price $568.00
Cayman SR 9186 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-13888-1
MFG.PART: 13888-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
SR 9186 is an inhibitor of the cytochrome P450 (CYP) isoform CYP3A4 (IC50 = 0.011 µM). It is highly selective for CYP3A4 over CYP3A5 (IC50 = 33 µM). SR 9186 inhibits metabolism of midazolam to 1’-hydroxy midazolam, testosterone to 6β-hydroxy testosterone, and vincristine to vincristine M1 in isolated human liver microsomes (HLMs) expressing recombinant CYP3A4 (IC50s = 9, 4, and 38 nM, respectively) but not microsomes expressing recombinant CYP3A5. It decreases lapatinib-induced quinoneimine-glutathione adduct formation in HLMs by 78% when used at a concentration of 2.5 µM.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-(4-cyano
CAS Number
1361414-26-7
Molecular Formula
C26H18N6O
Formula Weight
430.5
Purity
≥95%
Formulation
A solid
Solubility
- DMF: Soluble
- DMSO: Soluble
SMILES
O=C(NC1=CC=C(C2=CC=C(C#N)C=C2)C=C1)NC3=CC=C(C4=CC=NC5=C4N=CN5)C=C3
InChi Code
InChI=1S/C26H18N6O/c27-15-17-1-3-18(4-2-17)19-5-9-21(10-6-19)31-26(33)32-22-11-7-20(8-12-22)23-13-14-28-25-24(23)29-16-30-25/h1-14,16H,(H,28,29,30)(H2,31,32,33)
InChi Key
FEDMEJWMCJAMHE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-13888-1 |
|---|---|
| Supplier Part Number | 13888-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Canada |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1361414-26-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |