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Cayman WDR5-0103
List Price $90.00 Your Price $90.00
Cayman WDR5-0103 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-13945-5
MFG.PART: 13945-5
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
WD-repeat protein 5 (WDR5) is a scaffold protein commonly involved in the formation of nucleosome-modifying protein complexes with histones.1 For example, WDR5 is a component of a mixed-lineage leukemia (MLL) methyltransferase complex that targets histone 3.2 WDR5 can also be a component of histone acetyltransferase complexes and can directly bind methylated as well as unmodified histones.1,3 WDR5-0103 is a small molecule that binds a peptide-binding pocket on WDR5 (Kd = 450 nM), inhibiting the catalytic activity of the MLL core complex in vitro (IC50 = 39 µM).4,5
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3-[(3-methoxy
CAS Number
890190-22-4
Synonyms
- WD-Repeat Protein 5-0103
Molecular Formula
C21H25N3O4
Formula Weight
383.4
Purity
≥95%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 33.3 mg/mL
- DMF:PBS (pH 7.2) (1:1): 0.5 mg/mL
- DMSO: 16.6 mg/mL
- Ethanol: 12.5 mg/mL
λmax
212, 264 nm
SMILES
O=C(OC)C1=CC(NC(C2=CC=CC(OC)=C2)=O)=C(N3CCN(C)CC3)C=C1
InChi Code
InChI=1S/C21H25N3O4/c1-23-9-11-24(12-10-23)19-8-7-16(21(26)28-3)14-18(19)22-20(25)15-5-4-6-17(13-15)27-2/h4-8,13-14H,9-12H2,1-3H3,(H,22,25)
InChi Key
ZPLBXOVTSNRBFB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-13945-5 |
|---|---|
| Supplier Part Number | 13945-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 890190-22-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |