Cayman AH 6809

AH 6809 is an EP and DP receptor antagonist with nearly equal affinity for the cloned human EP₁, EP₂, EP₃-III, and DP₁ receptors.¹ AH 6809 blocks the PGE₂-induced accumulation of cAMP in COS cells transfected with the human EP₂ receptor.² It also blocks the accumulation of Ca²⁺ in Xenopus oocytes expressing the human EP₁ receptor.³ In the human and guinea pig, the activity profile of AH 6809 is similar to that of SC-19220, but it is somewhat more potent.⁴ In the mouse, AH 6809 has the highest affinity for the EP₂ receptor, but also acts as a weak ligand at the murine EP₁ and DP₁ receptors.⁵ In whole human platelets, AH 6809 is an effective antagonist of the antiaggregatory actions of PGD₂, but not PGI₂, with an EC₅₀ of about 5 x 10⁻⁵ M.⁶

WARNING This product is not for human or veterinary use.