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Cayman Carmofur
List Price $116.00 Your Price $116.00
Cayman Carmofur - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-14243-1
MFG.PART: 14243-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Carmofur is an inhibitor of acid ceramidase (IC50 = 79 nM for the rat enzyme) and a derivative of 5-flurouracil (Item No. ). It reduces acid ceramidase activity in a dose- and time-dependent manner and induces intracellular accumulation of various ceramide species, including C18 ceramide (Item No. ), C16 ceramide (Item No. ), and C14 ceramide (Item No. ) in SW403 colon and LNCaP prostate cancer cells. Carmofur induces apoptosis in SW403 cells without inhibiting DNA synthesis (IC50 = 1,212 mm for human thymidylate synthetase). It also reduces acid ceramidase activity and increases ceramide accumulation in mouse lung and brain when administered at doses of 10 and 30 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-fluoro-N-hexyl-3,4-dihydro-2H,4-dioxo-1-pyrimidinecarboxamide
CAS Number
61422-45-5
Synonyms
- HCFU
Molecular Formula
C11H16FN3O3
Formula Weight
257.3
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMF:PBS (pH 7.2) (1:1): 0.5 mg/mL
- DMSO: 20 mg/mL
- Ethanol: 5 mg/mL
λmax
211, 258 nm
SMILES
O=C1C(F)=CN(C(NCCCCCC)=O)C(N1)=O
InChi Code
InChI=1S/C11H16FN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18)
InChi Key
AOCCBINRVIKJHY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-14243-1 |
|---|---|
| Supplier Part Number | 14243-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 61422-45-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |