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Cayman CZC-24832
List Price $205.00 Your Price $205.00
Cayman CZC-24832 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-14307-10
MFG.PART: 14307-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
CZC-24832 is an inhibitor of PI3Kγ (IC50 = 0.025 µM in a binding assay). It is selective for PI3Kγ over PI3Kδ, PI3Kα, and PI3Kβ (IC50s = 7.9, >10, and 1.26 µM, respectively, in binding assays), as well as a panel of 154 lipid and protein kinases., CZC-24832 inhibits phosphorylation of Akt induced by complement component 5a (C5a) in RAW 264.7 macrophages (IC50 = 1.2 µM) and migration of isolated human granulocytes induced by fMLP (Item No. ; IC50 = 1 µM). It decreases disease severity in a mouse model of collagen-induced arthritis when administered at doses of 3 and 10 mg/kg.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-(2-amino-8-
CAS Number
1159824-67-5
Molecular Formula
C15H17FN6O2S
Formula Weight
364.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 5 mg/mL
- DMSO: 5 mg/mL
- DMSO:PBS (pH 7.2)(1:5): 0.2 mg/mL
λmax
218, 254, 292 nm
SMILES
O=S(C1=CC(C2=CN3C(C(F)=C2)=NC(N)=N3)=CN=C1)(NC(C)(C)C)=O.Cl
InChi Code
InChI=1S/C15H17FN6O2S.ClH/c1-15(2,3)21-25(23,24)11-4-9(6-18-7-11)10-5-12(16)13-19-14(17)20-22(13)8-10;/h4-8,21H,1-3H3,(H2,17,20);1H
InChi Key
GTDFAYLFDOPVIV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-14307-10 |
|---|---|
| Supplier Part Number | 14307-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1159824-67-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |