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Cayman PU 02
List Price
$174.00
Your Price
$174.00
Cayman PU 02 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-14312-10
MFG.PART:
14312-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
PU 02 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 with IC50 values ranging from 0.36 to 1.3 μM for human 5-HT3A, 5-HT3AB, 5-HT3AC, and 5-HT3AE in a FLIPR membrane potential assay using HEK293 cells expressing human recombinant receptors. It is selective for 5-HT3 over other Cys-loop containing receptors with IC50 values >100 μM for mouse, rat, and human nicotinic (nACh), human GABAA, and human glycine (Gly) receptors. PU 02 inhibits currents induced by 5-HT (Item No. ) in COS-7 cells expressing human 5-HT3A (IC50 = 0.49 μM). PU 02 also reduces growth of HepG2 cells in a dose-dependent manner via induction of cell cycle arrest at the g2/M phase and apoptosis.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6-[(1-naphthalenyl
CAS Number
313984-77-9
Molecular Formula
C16H12N4S
Formula Weight
292.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 10 mg/mL
- DMSO: 10 mg/mL
- DMSO:PBS (pH 7.2) (1:6): 0.14 mg/mL
λmax
224, 294 nm
SMILES
C12=NC=NC(SCC3=C(C=CC=C4)C4=CC=C3)=C1NC=N2
InChi Code
InChI=1S/C16H12N4S/c1-2-7-13-11(4-1)5-3-6-12(13)8-21-16-14-15(18-9-17-14)19-10-20-16/h1-7,9-10H,8H2,(H,17,18,19,20)
InChi Key
BGMSTNYJYPSLHN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-14312-10 |
|---|---|
| Supplier Part Number | 14312-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 313984-77-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |