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Cayman A-771726
List Price
$74.00
Your Price
$74.00
Cayman A-771726 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-14404-10
MFG.PART:
14404-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
A-771726 is an active metabolite of the prodrug leflunomide (Item No. ) that inhibits dihydroorotate dehydrogenase (DHODH; IC50 = 0.23 µM). A-771726 inhibits the production of prostaglandin E2 (PGE2; Item No. ) in TNF-α- or IL-1α-stimulated isolated human synoviocytes (IC50s = 7 and 3 μM, respectively). It inhibits the proliferation of isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations of 25 and 100 µM. A-771726 (3 and 10 mg/kg) delays disease onset and decreases neurological deficits in a rat model of experimental autoimmune encephalomyelitis (EAE) induced by complete Freund’s adjuvant (CFA) and M. tuberculosis. Formulations containing teriflunomide have been used in the treatment of multiple sclerosis.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-
CAS Number
163451-81-8
Synonyms
- Flucyamide
- HMR 1726
- SU 20
- Teriflunomide
Molecular Formula
C12H9F3N2O2
Formula Weight
270.2
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 21.6 mg/mL
- DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL
- DMSO: 10.7 mg/mL
λmax
203, 251, 288 nm
SMILES
O=C(/C(C#N)=C(O)/C)NC1=CC=C(C(F)(F)F)C=C1
InChi Code
InChI=1S/C12H9F3N2O2/c1-7(18)10(6-16)11(19)17-9-4-2-8(3-5-9)12(13,14)15/h2-5,18H,1H3,(H,17,19)/b10-7-
InChi Key
UTNUDOFZCWSZMS-YFHOEESVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-14404-10 |
|---|---|
| Supplier Part Number | 14404-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 163451-81-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |