Cayman GM 6001

GM 6001 is a potent, reversible broad spectrum inhibitor of zinc-containing proteases, including matrix metalloproteinases (MMPs).¹ It inhibits zinc-containing thermolysin and elastase from P. aeruginosa, both with K_i values of 20 nM.² GM 6001 inhibits MMP-1, -2, -7, -8, -9, -12, -13, -14, -16, and -26 with K_i or IC₅₀ values between 0.1 and 10 nM.^3,4,5,6 It inhibits disintegrin and metalloproteinase domain-containing (ADAM) proteins ADAM9, ADAM10, ADAM12, and ADAM17 at nanomolar concentrations.^7,8 It less potently inhibits lethal factor from B. anthracis anthrax lethal toxin (K_i = 2.74 μM).⁹ GM 6001 also impairs the growth of the human pathogen Chlamydia by inhibiting peptide deformylase, which contains iron rather than zinc (IC₅₀ = 38 nM).¹⁰

WARNING This product is not for human or veterinary use.