Cayman Nimodipine

Nimodipine is an inhibitor of L-type voltage-gated calcium (Ca_V) channels. It is selective for Ca_V1.2 over Ca_V1.3 channels (IC₅₀s = 0.139 and 2.7 µM, respectively), as well as R-, N-, and P/Q-type Ca_v channels at 10 µM.^, Nimodipine (0.72-24 nM) inhibits contractions induced by potassium, but not norepinephrine, in isolated rabbit aortic strips. It increases cerebral blood flow in anesthetized dogs when administered sublingually at doses ranging from 0.01 to 1 mg/kg. Nimodipine decreases necrosis of hippocampal CA1 pyramidal neurons and reduces increases in spontaneous movement and contralateral circling in a rat model of focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO).

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