Cayman Methyl-1-(5-Fluoropentyl)-1h-Indole-3-Carboxylate; Purity-

CD34 is a transmembrane phosphoglycoprotein and sialomucin protein that is commonly used as a marker for hematopoietic progenitor cells.^, It is composed of an N-terminal signaling peptide, a sialylated and O-glycosylated extracellular mucin domain, a cysteine-containing globular domain, a juxtamembrane stalk region, and an intracellular C-terminal tail. CD34 is expressed primarily in hematopoietic progenitor cells but is also expressed in mesenchymal stromal, muscle satellite, interstitial, epithelial and vascular endothelial progenitor, and adipose mesenchymal stem/stromal cells.^, It has both pro- and anti-adhesion activities, providing an anchor for L-selectin-mediated attachment of lymphocytes in vascular endothelial cells and blocking adhesion of bone marrow-derived mast cells in vitro.^, CD34 has commonly been used as a marker for the selection and enrichment of hematopoietic stem cells for bone marrow transplants. Cayman’s CD34 Monoclonal Antibody (Clone ICO-115) can be used for flow cytometry (FC) and immunocytochemistry (ICC) applications.

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