Cayman AMPK activator

AMPK activator is an indirect activator of AMP-activated protein kinase, AMPK (EC₅₀ = 11.7 μM).¹ It is thought to activate AMPK by inhibiting mitochondrial complex I, producing an increase in AMP levels.¹ AMPK activator stimulates glucose uptake in L6 myocytes and promotes phosphorylation of acetyl-CoA carboxylase, a known target of AMPK.¹ AMPK activator also decreases blood glucose concentrations in female Zucker diabetic rats, demonstrating its utility in whole animals.¹ At 50 μM, it inhibits the growth of multiple myeloma cells.² AMPK activator induces phosphorylation of raptor in PC3 prostate cancer cells, down-regulating mTORC1 signaling and reducing survivin expression.³

WARNING This product is not for human or veterinary use.