Cayman TBCA

Casein kinase 2 (CK2) is a kinase with many targets and diverse roles in cell signaling and disease.^1,2 TBCA is a selective, cell-permeable inhibitor of CK2 (IC₅₀ = 0.11 µM, K_i = 77 nM) that has minimal effect on a panel of 28 other kinases.³ It induces cell death in Jurkat adult T cell leukemia cells (DC₅₀ = 7.7 µM), driving caspase-dependent degradation of poly-ADP ribose polymerase while inhibiting CK2 activity.³ TBCA also supports a role for CK2 in platelet function and Akt phosphorylation but not protein splicing.^4,5

WARNING This product is not for human or veterinary use.