Cayman Concanavalin A

Concanavalin A is a plant lectin that has been found in jack bean (C. ensiformis) and is involved in plant defense.¹ It is formed from the 290-amino acid precursor protein pro-concanavalin A via deglycosylation by N-glycanase, peptide cleavage, and re-ligation to form the mature 237-amino acid monomer, which oligomerizes to form a tetramer. Each concanavalin A monomer has a carbohydrate recognition domain, which binds to α-D-mannose, α-D-glucose, and β-D-fructose, and a metal binding site that is involved in stability.^1,2 Concanavalin A has diverse biological activities, including erythrocyte agglutination, mitogenic stimulation, and anticancer activity.^1,2,3 It has been used in affinity purification of various glycoproteins, as well as to induce T cell activation in vitro and liver injury in experimental mouse models of autoimmune hepatitis.^4,5,6

WARNING This product is not for human or veterinary use.