Cayman Tetrodotoxin (Citrate); Purity- Greater Than Or Equal To 9

Name: Cayman Tetrodotoxin (Citrate); Purity- Greater Than Or Equal To 9
SKU: CAYM-14964-1
Price: 259.00 USD

List Price $259.00 Your Price $259.00

Cayman Tetrodotoxin (Citrate); Purity- Greater Than Or Equal To 98%; Size- 1 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)

NETA PART: CAYM-14964-1

MFG.PART: 14964-1

UNSPSC: 12352200

Manufacturer: Cayman

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Description

Product Description

Tetrodotoxin (TTX) is a potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through voltage-activated sodium (Na_v) channels, blocking nerve and muscle action potentials. It inhibits the Na_v current in frog muscle and squid axon with IC₅₀ values of 4.1 and 5.2 nM, respectively, and binds to rat brain membranes with a K_d value of 1.8 nM. TTX was used in Hodgkin and Huxley’s classic experiments to elucidate the physical biology of nerve action potentials and remains an indispensible neuroscience tool to pharmacologically dissect the contribution of the Na_v current in excitable neurons and to rationally design compounds for the treatment of neuropathic pain. This citrate-stabilized form of TTX is designed for improved solubility over pure TTX (Item No. ), which is insoluble in water and most organic solvents. This preparation of TTX citrate consists of TTX that has been dissolved in a citrate solution and then lyophilized.

WARNING This product is not for human or veterinary use.

Technical Information

Formal Name

(4R,4aR,5R,7S,9S,10S,10aR,11S,12S)-2-amino-1,4,4a,5,9,10-hexahydro-12-(hydroxymethyl)-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d]pyrimidine-4,7,10,11,12-pentol, 2-hydroxy-1,2,3-propanetricarboxylate

CAS Number

18660-81-6

Synonyms

TTX citrate

Molecular Formula

C₁₁H₁₇N₃O₈ • C₆H₈O₇

Formula Weight

511.4

Purity

≥98%

Formulation

A solid

Solubility

Citrate Buffer (pH 4.8): 30 mg/ml (100 mM)

SMILES

NC1=N[C@H](O)[C@@]2([H])[C@]3([H])[C@](CO)(O)[C@]([H])([C@@]4([H])O)O[C@@](O)(O3)[C@@H](O)[C@@]24N1.OC(CC(O)=O)(C(O)=O)CC(O)=O

InChi Code

InChI=1S/C11H17N3O8.C6H8O7/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5;7-3(8)1-6(13,5(11)12)2-4(9)10/h2-7,15-20H,1H2,(H3,12,13,14);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t2-,3-,4-,5+,6-,7+,9+,10-,11+;/m1./s1

InChi Key

YUJWMDOXROTQCW-JBHCYYBDSA-N

Shipping & Storage Information

Storage

-20°C

Shipping

Room Temperature in continental US; may vary elsewhere

Stability

≥ 4 years

Specifications

More Information
SKU	CAYM-14964-1
Featured	No
Supplier Part Number	14964-1
UM	EA
UNSPSC	12352200
Manufacturer	Cayman
MSDS URL	Click here
Temperature	-20
Refrigerated-Frozen	Refrigerated
CountryOfOrigin	United States
ProductLine	CAYM
Qty	1
MinOrderQty	1
Weight	7.000000
Lead Time	2
Hazardous	Y
CAS Number	18660-81-6
Energy Star	No
Green	No
ACT Ecolabel	No
Controlled	N

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NETA PART NO.	Quantity

Cayman Tetrodotoxin (Citrate); Purity- Greater Than Or Equal To 9

Product Description

Technical Information

Shipping & Storage Information

Product Title