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Cayman (±)-Ibutilide (hemifumarate)
List Price $329.00 Your Price $329.00
Cayman (±)-Ibutilide (hemifumarate) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-15011-100
MFG.PART: 15011-100
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
(±)-Ibutilide is a class III antiarrhythmic agent. It inhibits the rapidly activating delayed-rectifier potassium current (IKr) in AT-1 myocytes with an IC50 value of 20 nM. (±)-Ibutilide also enhances the late inward sodium current (INa) and increases the action potential duration in isolated guinea pig ventricular cells. It decreases ventricular fibrillation induced by the ATP-dependent potassium channel activator pinacidil (Item No. ) in Langendorff isolated perfused rabbit hearts when used at concentrations ranging from 3 to 30 µM. (±)-Ibutilide (15 µg/kg, i.v.) increases the effective refractory period (ERP) of the left and right atrium in anesthetized pigs. It prevents rapid pacing-induced atrial flutter in dogs when administered orally at doses ranging from 0.25 to 5 mg/kg. Formulations containing ibutilide have been used in the treatment of atrial arrhythmias.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[4-[4-
CAS Number
122647-32-9
Synonyms
- U-70226E
Molecular Formula
C20H36N2O3S • 1/2C4H4O4
Formula Weight
442.6
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- Ethanol: 5 mg/mL
- PBS (pH 7.2): 1 mg/mL
λmax
229 nm
SMILES
CS(NC1=CC=C(C(O)CCCN(CC)CCCCCCC)C=C1)(=O)=O.O=C(O)/C=C/C(O)=O
InChi Code
InChI=1S/2C20H36N2O3S.C4H4O4/c2*1-4-6-7-8-9-16-22(5-2)17-10-11-20(23)18-12-14-19(15-13-18)21-26(3,24)25;5-3(6)1-2-4(7)8/h2*12-15,20-21,23H,4-11,16-17H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+
InChi Key
PCIOHQNIRPWFMV-WXXKFALUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-15011-100 |
|---|---|
| Supplier Part Number | 15011-100 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 122647-32-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |