Cayman Prazosin (hydrochloride)

Prazosin is an antagonist of α₁-adrenergic receptors (α₁-ARs).^1,2 It selectively binds to α₁-ARs with K_i values of 0.2, 0.25, and 0.32 nM for the human recombinant α_1A-, α_1B-, and α_1D-ARs, respectively, over α₂-ARs (K_is = 340 and 3.7 nM in α_2A-AR-expressing HT-29 cells and α_2B-AR-expressing NG108 cells, respectively).^3,4 It also binds to melatonin receptor 3 (MT₃) in hamster brain membranes (IC₅₀ = 7.8 nM).⁵ Prazosin inhibits peripheral and central postsynaptic α₁-ARs with IC₅₀ values of 0.2 and 1.7 nM in isolated dog aorta and rat brain, respectively.¹ It decreases diastolic blood pressure in normal, renal hypertensive, and spontaneously hypertensive rats when administered at a dose of 1 mg/kg.⁶ Prazosin (1.5 mg/kg) increases the number of entries and percentage of time spent in the open arms of the elevated plus maze, indicating anxiolytic-like activity, in alcohol-consuming rats and also reduces alcohol intake and alcohol-seeking behavior in alcohol-preferring rats.^7,8

WARNING This product is not for human or veterinary use.