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Probucol is a potent antioxidant that inhibits the oxidation of cholesterol in LDL, which prevents the formation of macrophage-derived foam cells that lead to atherosclerotic vascular lesions.1 Probucol’s use is limited, however, because it leads to the reduction of HDL cholesterol as well.1 Probucol inhibits up to 80% efflux of cholesterol from J774 macrophages by impairing the translocation of ATP-binding cassette transporter A1 from intracellular compartments to the plasma membrane.2 In an in vivo mouse model of Huntington’s disease, 3.5 mg/kg/day probucol was shown to be protective against behavioral and striatal oxidative damage by increasing the activity of glutathione peroxidase.3
WARNING This product is not for human or veterinary use.