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Cayman CCG-203971
List Price $98.00 Your Price $98.00
Cayman CCG-203971 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-15075-10
MFG.PART: 15075-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Signaling through small g proteins of the RhoA subfamily, including RhoC, induces actin-regulated cytosolic-to-nuclear translocation of the oncogene product megakaryoblastic leukemia 1 (MKL1), which binds to serum response factor (SRF). The MKL1/SRF complex, in turn, activates the transcription of serum response element (SRE) regulated genes, stimulating cell migration, a process that is central to metastasis. CCG-203971 is an inhibitor of SRE activation in the prostate cancer cell line PC-3 (IC50 = 6.4 μM), with 87% inhibition of SRE activation achieved at 100 μM. This compound also inhibits PC-3 cell migration (IC50 = 4.2 μM), as determined by a scratch wound assay. CCG-203971 causes no cytotoxicity when evaluated by WST-1 assay. It is well tolerated in normal mice up to doses of 100 mg/kg given intraperitoneally over five days.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-(4-chloro
CAS Number
1443437-74-8
Molecular Formula
C23H21ClN2O3
Formula Weight
408.9
Purity
≥90%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 25 mg/mL
- Ethanol: 50 mg/mL
λmax
252, 281 nm
SMILES
O=C(N1CCCC(C(NC2=CC=C(Cl)C=C2)=O)C1)C3=CC(C4=CC=CO4)=CC=C3
InChi Code
InChI=1S/C23H21ClN2O3/c24-19-8-10-20(11-9-19)25-22(27)18-6-2-12-26(15-18)23(28)17-5-1-4-16(14-17)21-7-3-13-29-21/h1,3-5,7-11,13-14,18H,2,6,12,15H2,(H,25,27)
InChi Key
HERLZBNILRVHQN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-15075-10 |
|---|---|
| Supplier Part Number | 15075-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1443437-74-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |