We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cayman PF-429242 (hydrochloride)
List Price $55.00 Your Price $55.00
Cayman PF-429242 (hydrochloride) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-15140-1
MFG.PART: 15140-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
PF-429242 is an inhibitor of site-1 protease with an IC50 value of 170 nM for human recombinant site-1 protease. It is selective for site-1 protease over trypsin, elastase, proteinase K, plasmin, kallikren, factor XIa, thrombin, and furin at concentrations up to 100 μM. PF-429242 completely inhibits proteolytic processing and nuclear translocation of sterol regulatory element-binding protein (SREBP) in HepG2 cells at a concentration of 10 μM. It also reduces expression of HMG-CoA synthase and fatty acid synthase (EC50s = 0.3 and 2 μM, respectively) and inhibits cholesterol synthesis (EC50 = 600 nM) in HepG2 cells and reduces cholesterol and fatty acid synthesis in CD-1 mice. PF-429242 inhibits replication of dengue virus serotypes 1-4 in infected HeLa cells. It also reduces growth of T98G, U87-mg, and A172 glioblastoma cells (IC50s = 0.32, 15.2, and 27.6 μM, respectively).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[(diethyl
CAS Number
2248666-66-0
Molecular Formula
C25H35N3O2 • 2HCl
Formula Weight
482.5
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- Ethanol: 30 mg/mL
- PBS (pH 7.2): 10 mg/mL
λmax
272 nm
SMILES
O=C(C1=CC=C(CN(CC)CC)C=C1)N(CCC2=CC=CC=C2OC)[C@H]3CNCC3.Cl.Cl
InChi Code
InChI=1S/C25H35N3O2.2ClH/c1-4-27(5-2)19-20-10-12-22(13-11-20)25(29)28(23-14-16-26-18-23)17-15-21-8-6-7-9-24(21)30-3;;/h6-13,23,26H,4-5,14-19H2,1-3H3;2*1H/t23-;;/m1../s1
InChi Key
GSUZWFZKTIOWTI-MQWQBNKOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-15140-1 |
|---|---|
| Supplier Part Number | 15140-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2248666-66-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |