Cayman mL-252 (hydrochloride)

mL-252 is a potent and selective inhibitor of the voltage-gated potassium channel subtype K_v7.2 (IC₅₀ = 69 nM in a patch clamp assay). It is the (S)-enantiomer and is more potent than the (R)-enantiomer and the racemic mixture (IC₅₀s = 944 and 160 nM, respectively). It is selective for K_v7.2 over other K_v channel subtypes, >68 g protein-coupled receptors, transporters, L- and N-type calcium channels, and K_ATP and hERG potassium channels though it does inhibit the melatonin MT₁ receptor 61% when used at a concentration of 10 µM.

WARNING This product is not for human or veterinary use.