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Cayman Ketoconazole
List Price $134.00 Your Price $134.00
Cayman Ketoconazole - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-15212-1
MFG.PART: 15212-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Ketoconazole is a broad-spectrum triazole antifungal agent that has activity against C. albicans, C. krusei, C. tropicalis, C. glabrata, C. parapsilosis, C. neoformans, and A. fumigatus strains (IC50s = 0.031-8 µg/mL). It inhibits the fungal cytochrome P450 (CYP) isoform CYP51, also known as lanosterol 14α-demethylase, which arrests ergosterol (Item No. ) biosynthesis at the fungal membrane. Ketoconazole also inhibits human CYP3A4 (IC50 = 0.54 µM). Formulations containing ketoconazole have been used in the treatment of fungal infections.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1-
CAS Number
65277-42-1
Synonyms
- R 41400
Molecular Formula
C26H28Cl2N4O4
Formula Weight
531.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 5 mg/mL
- DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL
- DMSO: 2 mg/mL
- Ethanol: 1 mg/mL
λmax
244, 297 nm
SMILES
CC(N1CCN(C2=CC=C(OC[C@@H]3O[C@](C4=CC=C(Cl)C=C4Cl)(CN5C=CN=C5)OC3)C=C2)CC1)=O
InChi Code
InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m0/s1
InChi Key
XMAYWYJOQHXEEK-OZXSUGGESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-15212-1 |
|---|---|
| Supplier Part Number | 15212-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 65277-42-1 |
| Energy Star | No |
| Green | No |
| Controlled | N |