Cayman Cu CPT 22

Cu CPT 22 is an antagonist of toll-like receptor 1 (TLR1) and TLR2 heterodimers (TLR1/TLR2; K_i = 0.41 µM). It inhibits nitric oxide (NO) production induced by the TLR2 agonist Pam₃CSK₄ (Item No. ) in RAW 264.7 cells (IC₅₀ = 0.58 µM). It is selective for TLR1/TLR2 over TLR2/TLR6 and TLR3, -4, and -7 homodimers, as well as 10 kinases at 0.5 µM. Cu CPT 22 (8 µM) inhibits Pam₃CSK₄-induced release of TNF-α and IL-1β in RAW 264.7 cells by 60 and 95%, respectively.

WARNING This product is not for human or veterinary use.