Cayman BCH

The L-type amino acid transporters (LATs) are Na⁺-dependent neutral amino acid transporters. They include four members in two sub-families, with LAT1 and LAT2 belonging to solute carrier (SLC) family 7 and LAT3 and LAT4 being members of SLC43. LAT1 is overexpressed in many tumors and contributes to ribosome biogenesis and cell growth by supporting mTOR complex 1 (mTORC1) signaling. BCH is an inhibitor of LAT1 that blocks the uptake of L-leucine with an IC₅₀ value of 131.5 µM.^, It can inhibit all members of the LAT family at a concentration of 10 mm. In addition to eliminating the uptake of neutral amino acids, BCH suppresses mTORC1 signaling that drives DNA synthesis and cell proliferation.^, LAT1 is also essential for the uptake of amino acid-related compounds, like L-DOPA (Item No. ), through the blood-brain barrier, and this can be inhibited by BCH.^,

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