Cayman BCH

The L-type amino acid transporters (LATs) are Na⁺-dependent neutral amino acid transporters.¹ They include four members in two sub-families, with LAT1 and LAT2 belonging to solute carrier (SLC) family 7 and LAT3 and LAT4 being members of SLC43.¹ LAT1 is overexpressed in many tumors and contributes to ribosome biogenesis and cell growth by supporting mTOR complex 1 (mTORC1) signaling.² BCH is an inhibitor of LAT1 that blocks the uptake of L-leucine with an IC₅₀ value of 131.5 µM.^3,4 It can inhibit all members of the LAT family at a concentration of 10 mm.¹ In addition to eliminating the uptake of neutral amino acids, BCH suppresses mTORC1 signaling that drives DNA synthesis and cell proliferation.^1,2 LAT1 is also essential for the uptake of amino acid-related compounds, like L-DOPA (Item No. 13248), through the blood-brain barrier, and this can be inhibited by BCH.^4,5

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