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Cayman LY379268
List Price
$359.00
Your Price
$359.00
Cayman LY379268 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-15351-10
MFG.PART:
15351-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
LY379268 is a potent, brain-permeable, and selective agonist of group II metabotropic glutamate receptors (mGluRs), subtypes mGluR2 and mGluR3.1 In an assay of second messenger response, LY379268 exhibits EC50 values of 2.69 and 4.48 nM for human mGluR2 and mGluR3, respectively, with at least 80-fold selectivity over group I and III mGluRs.1 In a displacement assay, LY379268 displays no agonist or antagonist activity against NMDA, AMPA, or kainate receptors up to a concentration of 100 µM.1 However, it may influence the level of AMPA receptor trafficking in rat prefrontal cortical neurons.2 LY379268 confers a neuroprotective effect to the CA1 of the hippocampus in a gerbil model of induced ischemia at a dose of 10 mg/kg.3 In rats, LY379268 (3 mg/kg) raises the extracellular dopamine level to 168% of the basal level in the prefrontal cortex.4
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(1R,4R,5S,6R)-
CAS Number
191471-52-0
Molecular Formula
C7H9NO5
Formula Weight
187.2
Purity
≥99%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- Water: 25 mm
SMILES
[H][C@]1([C@@H]2C(O)=O)[C@]2([H])[C@@](C(O)=O)(N)CO1
InChi Code
InChI=1S/C7H9NO5/C8-7(6(11)12)1-13-4-2(3(4)7)5(9)10/h2-4H,1,8H2,(H,9,10)(H,11,12)/t2-,3-,4+,7+/m1/s1
InChi Key
YASVRZWVUGJELU-MDASVERJSA-N
Shipping & Storage Information
Storage
4°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-15351-10 |
|---|---|
| Supplier Part Number | 15351-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | 4 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 191471-52-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |