Cayman (Glp1)-Apelin-13 (trifluoroacetate salt)

The apelin gene encodes a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids: apelin-36 (Item No. ), apelin-17, and apelin-13 (Item No. ), respectively. Apelin-13 is an endogenous ligand of the APJ receptor, activating this g protein-coupled receptor with an EC₅₀ value of 0.37 nM.^, (Glp1)-Apelin-13 is a pyroglutamylated form of apelin-13, in that the N-terminal glutamine residue is cyclized to pyroglutamic acid. Like apelin-13, this compound is a potent APJ receptor agonist (EC₅₀ = 0.30 nM). (Glp1)-Apelin-13 is the major apelin isoform in the plasma of healthy human subjects. It can have vasoconstrictor and antipyretic effects in vitro and in vivo.^,,

WARNING This product is not for human or veterinary use.