Cayman MF498

Prostaglandin E₂ (PGE₂; Item No. ) activates four E prostanoid (EP) receptors, EP_1-4. EP₄ is a Gs protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, inflammation, cancer, and atherosclerosis.^,, MF498 is a selective EP₄ receptor antagonist (K_i = 0.7 nM versus a K_i > 1 µM for other EP receptors). In HEK293 cells expressing the human EP₄ receptor, MF498 inhibits EP ligand induced activity with an IC₅₀ value of 1.7 nM. In various animal models for arthritis, MF498 has been shown to inhibit inflammation without gastrointestinal toxicity (ED₅₀ values as low as 0.02 mg/kg/day).

WARNING This product is not for human or veterinary use.