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Cayman OICR-9429
List Price $63.00 Your Price $63.00
Cayman OICR-9429 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-16095-1
MFG.PART: 16095-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
WD-repeat protein 5 (WDR5) is a scaffold protein commonly involved in the formation of nucleosome-modifying protein complexes with histones. For example, WDR5 is a component of a mixed-lineage leukemia (MLL) methyltransferase complex that targets histone 3. WDR5 can also be a component of histone acetyltransferase complexes and can directly bind methylated as well as unmodified histones., OICR-9429 is a chemical probe that inhibits the interaction of WDR5 with peptide regions of MLL and Histone 3, demonstrating >100-fold selectivity over other chromatin reader domains, methyltransferases, and other non-epigenetic targets. It selectively binds to WDR5 (Kd = 24-52 nM) and disrupts its interaction with MLL1 and RbBP5 in cells (IC50 = <1 µM). For more information on OICR-9429 please visit the . The negative control, OICR-0547, for OICR-9429 is also available exclusively through the SGC. You can submit a request to receive the negative control .
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-(4-(4-methylpiperazin-1-yl)-3-(morpholinomethyl)-[1,1-biphenyl]-3-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide
CAS Number
1801787-56-3
Molecular Formula
C29H32F3N5O3
Formula Weight
555.6
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMSO: .5 mg/mL (with gentle warming)
- Methanol: .5 mg/mL (with gentle warming)
λmax
259 nm
SMILES
O=C(C1=CNC(C=C1C(F)(F)F)=O)NC2=CC(C3=CC(CN4CCOCC4)=CC=C3)=CC=C2N5CCN(C)CC5
InChi Code
InChI=1S/C29H32F3N5O3/c1-35-7-9-37(10-8-35)26-6-5-22(21-4-2-3-20(15-21)19-36-11-13-40-14-12-36)16-25(26)34-28(39)23-18-33-27(38)17-24(23)29(30,31)32/h2-6,15-18H,7-14,19H2,1H3,(H,33,38)(H,34,39)
InChi Key
DJOVLOYCGXNVPI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16095-1 |
|---|---|
| Supplier Part Number | 16095-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1801787-56-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |