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Cayman TIQ-A
List Price $436.00 Your Price $436.00
Cayman TIQ-A - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-16112-10
MFG.PART: 16112-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Poly(ADP-ribose) polymerase 1 (PARP1) is a critical DNA repair enzyme involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in many pathological conditions including ischemia and reperfusion injury, asthma-related inflammation, and atherogenesis.1,2,3 TIQ-A is a PARP1 inhibitor (IC50 = 450 nM in cultured mouse cortical neurons).1 It displays neuroprotective effects in cultured mouse cortical neurons injured by oxygen-glucose deprivation (IC50 = 0.15 µM). TIQ-A has been used to inhibit eosinophilic infiltration into airways of OVA-challenged mice and to induce the regression of atherosclerotic plaques in high-fat fed apolipoprotein E(-/-) mice.2,3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
thieno[2,3-c]
CAS Number
420849-22-5
Molecular Formula
C11H7NOS
Formula Weight
201.2
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 15 mg/mL
- DMF:PBS (pH 7.2) (1:8): 0.1 mg/mL
- DMSO: 10 mg/mL
- Ethanol: 0.5 mg/mL
λmax
230, 341, 355 nm
SMILES
O=C1NC2=C(C=CS2)C3=C1C=CC=C3
InChi Code
InChI=1S/C11H7NOS/c13-10-8-4-2-1-3-7(8)9-5-6-14-11(9)12-10/h1-6H,(H,12,13)
InChi Key
LQJVOLSLAFIXSV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16112-10 |
|---|---|
| Supplier Part Number | 16112-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Ukraine |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 420849-22-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |