Cayman Estradiol 17-( Betad-Glucuronide) (Sodium Salt); Purity-

Estradiol 17-(β-D-glucuronide) (E₂17G) is an estrogen metabolite formed in the liver and subsequently excreted in bile.¹ It acts as a substrate of the multidrug resistance protein 2 (MRP2; K_m = 75 µM), and through MRP2-mediated transport, functions as a cholestatic agent, decreasing bile flow.^1,2 In addition to binding to the MRP2 transport site, E₂17G has been shown to bind to an allosteric site that through positive cooperativity activates its own transport via MRP2 and the transport of other MRP2 substrates, including the non-cholestatic estrogen metabolite, estradiol 3-(β-D-glucuronide) (E₂3G; Item No. 16155).^2,3 E₂17G has also been reported to be transported by MDR1, MRP1, MRP3, MRP4, MRP7, ABCG2 (a breast cancer resistance protein transporter), and the rat organic anion-transporting polypeptides 1-4.²

WARNING This product is not for human or veterinary use.