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Cayman Seco Rapamycin (sodium salt)
List Price
$130.00
Your Price
$130.00
Cayman Seco Rapamycin (sodium salt) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-16158-1
MFG.PART:
16158-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Rapamycin (Item No. ) is a natural macrolide immunosuppressant that activates mTORC1. Seco rapamycin (sodium salt) is a nonenzyme-dependent degradation product of rapamycin (Item No. ) resulting from ester hydration followed by dehydration. It has less than 4% of the potency of rapamycin in a thymocyte proliferation assay. Rapamycin quickly degrades to two ring-opened products, including seco rapamycin, in the cytoplasm or in homogenates of Caco-2 cells. Like rapamycin, seco rapamycin is secreted from cells by P-glycoprotein and metabolized to a common dihydro species. While seco rapamycin poorly activates mTOR, it mimics rapamycin in its ability to inhibit the proteasome.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
[2R-[2α,2(S*),
CAS Number
148554-65-8
Molecular Formula
C51H78NO13 • Na
Formula Weight
936.2
Purity
≥85%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 25 mg/mL
- Ethanol: 25 mg/mL
- PBS (pH 7.2): 5 mg/mL
λmax
277, 289 nm
SMILES
O[C@@H]1CC[C@@H](C[C@@H](C)/C=C/C([C@H](C)/C=C(C)/[C@@H](O)[C@@H](OC)C([C@H](C)C[C@H](C)/C=C/C=C/C=C([C@@H](OC)C[C@@H]2CC[C@@H](C)[C@](O)(C(C(N3CCCC[C@H]3C([O-])=O)=O)=O)O2)\C)=O)=O)C[C@H]1OC.[Na+]
InChi Code
InChI=1S/C51H79NO13.Na/c1-31(26-35(5)45(55)47(64-10)46(56)36(6)28-34(4)41(53)23-19-32(2)27-38-21-24-42(54)44(29-38)63-9)16-12-11-13-17-33(3)43(62-8)30-39-22-20-37(7)51(61,65-39)48(57)49(58)52-25-15-14-18-40(52)50(59)60;/h11-13,16-17,19,23,28,31-32,34-35,37-40,42-44,46-47,54,56,61H,14-15,18,20-22,24-27,29-30H2,1-10H3,(H,59,60);/q;+1/p-1/b13-11+,16-12+,23-19+,33-17+,36-28+;/t31-,32+,34-,35-,37-,38+,39+,40+,42-,43+,44-,46-,47+,51-;/m1./s1
InChi Key
DNMSBJYMPJMFNS-OWGFPTNRSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16158-1 |
|---|---|
| Supplier Part Number | 16158-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 148554-65-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |