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Cayman 5-Methyl-2-Deoxycytidine; Purity- Greater Than Or Equal T
List Price
$341.00
Your Price
$341.00
Cayman 5-Methyl-2-Deoxycytidine; Purity- Greater Than Or Equal To 98%; Size- 5 G; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-16166-5
MFG.PART:
16166-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Gilteritinib is an inhibitor of FMS-related tyrosine kinase 3 (FLT3; IC50 = 5 nM for the wild-type enzyme). It inhibits mutant forms of FLT3, including FLT3 with the internal tandem duplication mutation (FLT3-ITD), FLT3-ITD expressing the F691L mutation, and FLT3 with various tyrosine kinase domain mutations (FLT3-TKD; IC50s =1.4-1.8, 12.2, and 0.7-2 nM, respectively). Gilteritinib also inhibits Axl and c-Kit with IC50 values of 41 and 102 nM, respectively. It decreases the viability of blast cells isolated from patients with relapsed acute myeloid leukemia (AML) in a concentration-dependent manner. Formulations containing gilteritinib have been used in the treatment of AML.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6-ethyl-3-
CAS Number
1254053-43-4
Synonyms
- ASP2215
Molecular Formula
C29H44N8O3
Formula Weight
552.7
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/ml
- DMSO: 30 mg/ml
- DMSO:PBS (pH 7.2) (1:7): 0.125 mg/ml
- Ethanol: 20 mg/ml
λmax
213, 314, 366 nm
SMILES
CN1CCN(C2CCN(C3=CC=C(NC4=NC(NC5CCOCC5)=C(CC)N=C4C(N)=O)C=C3OC)CC2)CC1
InChi Code
InChI=1S/C29H44N8O3/c1-4-23-28(31-20-9-17-40-18-10-20)34-29(26(33-23)27(30)38)32-21-5-6-24(25(19-21)39-3)37-11-7-22(8-12-37)36-15-13-35(2)14-16-36/h5-6,19-20,22H,4,7-18H2,1-3H3,(H2,30,38)(H2,31,32,34)
InChi Key
GYQYAJJFPNQOOW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16166-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 16166-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 838-07-3 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |