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Cayman EPZ004777 (formate)
List Price
$36.00
Your Price
$36.00
Cayman EPZ004777 (formate) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-16173-500
MFG.PART:
16173-500
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
EPZ004777 is a potent inhibitor of DOT1L (IC50 = 400 pM) that selectively kills mixed lineage leukemia (MLL) cells in vitro and prolongs survival in an MLL xenograft mouse model.1,2,3,4 It displays >1,000-fold selectivity for DOT1L relative to a panel of histone methyltransferases.1 DOT1L inhibition by EPZ004777 has also been shown to accelerate the reprogramming of somatic cells into induced pluripotent stem cells.5
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
7-[5-deoxy-5-
Molecular Formula
C28H41N7O4 • CH2O2
Formula Weight
585.7
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 10 mg/mL
- DMSO: 10 mg/mL
- Ethanol: 10 mg/mL
- Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/mL
λmax
242, 271 nm
SMILES
CC(C)(C)C1=CC=C(NC(NCCCN(C(C)C)C[C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C=CC4=C3N=CN=C4N)O2)=O)C=C1.O=CO
InChi Code
InChI=1S/C28H41N7O4.CH2O2/c1-17(2)34(13-6-12-30-27(38)33-19-9-7-18(8-10-19)28(3,4)5)15-21-22(36)23(37)26(39-21)35-14-11-20-24(29)31-16-32-25(20)35;2-1-3/h7-11,14,16-17,21-23,26,36-37H,6,12-13,15H2,1-5H3,(H2,29,31,32)(H2,30,33,38);1H,(H,2,3)/t21-,22-,23-,26-;/m1./s1
InChi Key
CTNCHYJQYACUDR-XRJUUMFPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16173-500 |
|---|---|
| Supplier Part Number | 16173-500 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |