Cayman 2-Deoxyadenosine-5-Monophosphate (Hydrate); Purity- Grea

Name: Cayman 2-Deoxyadenosine-5-Monophosphate (Hydrate); Purity- Grea
SKU: CAYM-16218-1
Price: 78.00 USD

List Price $78.00 Your Price $78.00

Cayman 2-Deoxyadenosine-5-Monophosphate (Hydrate); Purity- Greater Than Or Equal To 95%; Size- 1 G; - CAYM (Additional S&H Or Hazmat Fees May Apply)

NETA PART: CAYM-16218-1

MFG.PART: 16218-1

UNSPSC: 12352200

Manufacturer: Cayman

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Description

Product Description

Calcitonin is a peptide hormone that lowers blood calcium level and inhibits bone resorption.^, It belongs to the calcitonin family of peptides, which also includes amylin (Item No. ), calcitonin gene-related peptide (Item No. ), and adrenomedullin. The binding of salmon calcitonin to the human calcitonin receptor (CTR) is not modulated by receptor activity-modifying proteins (RAMPs), which influence affinity of human calcitonin (Item No. ) to CTR.^, Salmon calcitonin binds to human CTR2 with IC₅₀ values of 0.933, 0.224, 0.134, and 0.317 nM alone and with RAMP1, 2, or 3, respectively. It induces cAMP accumulation in COS-7 cells transfected with CTR2 (EC₅₀ = 0.166 nM). Salmon calcitonin inhibits bone resorption by osteoclasts in a pit formation assay using rat bone slices (ID₅₀ = 0.003 pg/mL) and lowers calcium level in vivo in a bioassay of hypocalcemia in rats (ED₁₅ = 33.9 mg/kg). Formulations containing salmon calcitonin have been used to treat hypercalcemia, bone destruction by osteoporosis, and Pagets disease.

WARNING This product is not for human or veterinary use.

Technical Information

Formal Name

L-cysteinyl-L-seryl-L-asparaginyl-L-leucyl-L-seryl-L-threonyl-L-cysteinyl-L-valyl-L-leucylglycyl-L-lysyl-L-leucyl-L-seryl-L-glutaminyl-L-α-glutamyl-L-leucyl-L-histidyl-L-lysyl-L-leucyl-L-glutaminyl-L-threonyl-L-tyrosyl-L-prolyl-L-arginyl-Lthreonyl-L-asparaginyl-L-threonylglycyl-L-serylglycyl-L-threonyl-L-prolinamide, cyclic (1→7)-disulfide, trifluoroacetate salt

CAS Number

171052-37-2

Synonyms

Calcitonin (1-32) (salmon)
Salcatonin
sCT
Thyrocalcitonin (salmon)

Molecular Formula

C₁₄₅H₂₄₀N₄₄O₄₈S₂ • XCF₃COOH

Formula Weight

3431.9

Purity

≥95%

Formulation

A lyophilized powder

Solubility

Water: 1 mg/ml

SMILES

NC([C@@H]1CCCN1C([C@@]([C@@H](C)O)([H])NC(CNC([C@H](CO)NC(CNC([C@@]([C@@H](C)O)([H])NC([C@H](CC(N)=O)NC([C@@]([C@@H](C)O)([H])NC([C@H](CCCNC(N)=N)NC([C@@H]2CCCN2C([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCC(N)=O)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC(CNC([C@H](CC(C)C)NC([C@H](C(C)C)NC([C@@H](N3)CSSC[C@H](N[H])C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@]([C@@H](C)O)([H])C3=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CC4=CN=CN4)=O)=O)=O)=O)=O)CC5=CC=C(O)C=C5)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.FC(F)(C(O)=O)F

InChi Code

InChI=1S/C145H240N44O48S2.C2HF3O2/c1-65(2)45-86(175-139(232)110(70(11)12)183-136(229)99-63-239-238-62-79(148)117(210)178-96(59-191)134(227)174-92(52-104(151)202)131(224)172-90(49-69(9)10)129(222)180-98(61-193)135(228)187-114(74(16)197)142(235)181-99)118(211)158-55-106(204)162-80(25-18-20-40-146)120(213)169-89(48-68(7)8)128(221)179-97(60-192)133(226)167-83(34-37-102(149)200)122(215)165-85(36-39-109(207)208)123(216)171-88(47-67(5)6)127(220)173-91(51-77-54-156-64-161-77)130(223)164-81(26-19-21-41-147)121(214)170-87(46-66(3)4)126(219)166-84(35-38-103(150)201)125(218)186-113(73(15)196)141(234)177-94(50-76-30-32-78(199)33-31-76)143(236)189-44-24-29-101(189)137(230)168-82(27-22-42-157-145(154)155)124(217)185-112(72(14)195)140(233)176-93(53-105(152)203)132(225)184-111(71(13)194)138(231)160-56-107(205)163-95(58-190)119(212)159-57-108(206)182-115(75(17)198)144(237)188-43-23-28-100(188)116(153)209;3-2(4,5)1(6)7/h30-33,54,64-75,79-101,110-115,190-199H,18-29,34-53,55-63,146-148H2,1-17H3,(H2,149,200)(H2,150,201)(H2,151,202)(H2,152,203)(H2,153,209)(H,156,161)(H,158,211)(H,159,212)(H,160,231)(H,162,204)(H,163,205)(H,164,223)(H,165,215)(H,166,219)(H,167,226)(H,168,230)(H,169,213)(H,170,214)(H,171,216)(H,172,224)(H,173,220)(H,174,227)(H,175,232)(H,176,233)(H,177,234)(H,178,210)(H,179,221)(H,180,222)(H,181,235)(H,182,206)(H,183,229)(H,184,225)(H,185,217)(H,186,218)(H,187,228)(H,207,208)(H4,154,155,157);(H,6,7)/t71-,72-,73-,74-,75-,79+,80+,81+,82+,83+,84+,85+,86+,87+,88+,89+,90+,91+,92+,93+,94+,95+,96+,97+,98+,99+,100+,101+,110+,111+,112+,113+,114+,115+;/m1./s1

InChi Key

GYTJOAZTZPTMIF-LXQLIYPUSA-N

Shipping & Storage Information

Storage

-20°C

Shipping

Room Temperature in continental US; may vary elsewhere

Stability

≥ 4 years

Specifications

More Information
SKU	CAYM-16218-1
Featured	No
Supplier Part Number	16218-1
UM	EA
UNSPSC	12352200
Manufacturer	Cayman
MSDS URL	Click here
Temperature	-20
Refrigerated-Frozen	Refrigerated
CountryOfOrigin	United States
ProductLine	CAYM
Qty	1
MinOrderQty	1
Weight	7.000000
Lead Time	2
Hazardous	N
CAS Number	653-63-4
Energy Star	No
Green	No
ACT Ecolabel	No
Controlled	N

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NETA PART NO.	Quantity

Cayman 2-Deoxyadenosine-5-Monophosphate (Hydrate); Purity- Grea

Product Description

Technical Information

Shipping & Storage Information

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