Cayman Gnf-5; Purity- Greater Than Or Equal To 95%; Size- 50 Mg;

GNF-5 is an allosteric inhibitor of Bcr-Abl (IC₅₀ = 0.121 µM) and a derivative of GNF-2 (Item No. 16253).¹ It also inhibits the Bcr-Abl mutants Bcr-Abl^G250E, Bcr-Abl^E255V, and Bcr-Abl^M351T (IC₅₀s = 4.52, 0.38, and 0.93 µM, respectively).² GNF-5 inhibits the growth of Ba/F3 cells (IC₅₀ = 0.145 µM).¹ It reduces viral titers in Vero cells infected with infectious bronchitis virus (IBV), a coronavirus, when used at a concentration of 10 µM via inhibition of IBV surface glycoprotein-induced syncytia formation and virus-cell fusion.³ GNF-5 (75 mg/kg) increases survival in a recalcitrant mutant Bcr-Abl^T315I mouse bone marrow transplantation model when administered alone or in combination with nilotinib.²

WARNING This product is not for human or veterinary use.