Cayman Jnj-26854165; Purity- Greater Than Or Equal To 98%; Size-

The cytochrome P450 (CYP) isoform CYP17 is also known as steroid 17α-hydroxylase/17,20 lyase because it catalyzes both 17α-hydroxylase and 17,20 lyase reactions in the synthesis of steroids, including androgens, estrogens, glucocorticoids, and mineralocorticoids. Galeterone is a CYP17 inhibitor (IC₅₀ = 300 nM) that has been shown to competitively block synthetic androgen binding (EC₅₀ = 845 nM) and to antagonize the androgen receptor in transcriptional activation assays. Galeterone can inhibit the growth of castration-resistant prostate cancer cells with an IC₅₀ value of 2.9 µM and demonstrates synergy with everolimus (Item No. ) or gefitinib (Item No. ) for growth inhibition.^,

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