Cayman Ly2940680; Purity- Greater Than Or Equal To 98%; Size- 1 M

Oxysophocarpine is an alkaloid that has been found in S. flavescens and has diverse biological activities, including neuroprotective, anticancer, anti-inflammatory, and analgesic properties.^,, It increases cell survival and decreases lactate dehydrogenase (LDH) leakage and loss of mitochondrial membrane potential in rat primary hippocampal neurons in a model of oxygen-glucose deprivation and reperfusion injury when used at concentrations of 1, 2, and 5 μM. Oxysophocarpine (5 μM) inhibits proliferation and reduces migration and invasion of SCC-9 and SCC-15 oral squamous cell carcinoma (OSCC) cells in vitro. It reduces tumor growth in an SCC-9 mouse xenograft model when administered at a dose of 80 mg/kg. Oxysophocarpine (40 and 80 mg/kg) inhibits xylene-induced ear swelling and carrageenan-induced paw edema in mice. It also reduces carrageenan-induced decreases in the paw withdrawal threshold and prevents carrageenan-induced increases in paw tissue levels of TNF-α, IL-1β, IL-6, and prostaglandin E₂ (PGE₂; Item No. ) in mice when administered at a dose of 80 mg/kg.

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