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Cayman PPQ-102
List Price
$781.00
Your Price
$781.00
Cayman PPQ-102 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-16275-50
MFG.PART:
16275-50
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
The cystic fibrosis (CF) gene encodes a cAMP-regulated chloride channel, the CF transmembrane conductance regulator (CFTR). PPQ-102 is a cell-permeable pyrimido-pyrrolo-quinoxalinedione that reversibly inhibits CFTR chloride channels with an IC50 value of 90 nM.1 At 0.5-5 µM, PPQ-102 has been used to reduce the size and number of renal cysts in a neonatal kidney organ culture model of polycystic kidney disease.1 At 1 µM, PPQ-102 can increase vascular endothelial growth factor-A production in cultured airway epithelial NCI-H292 cells, triggering epidermal growth factor receptor phosphorylation.2
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6,7-dihydro-7,9-dimethyl-6-(5-methyl-2-furanyl)-11-phenyl-pyrimido[4,5:3,4]pyrrolo[1,2-a]quinoxaline-8,10(5H,9)-dione
CAS Number
931706-15-9
Synonyms
- CFTR Inhibitor IV
- Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor IV
Molecular Formula
C26H22N4O3
Formula Weight
438.5
Purity
≥95%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 0.2 mg/mL
λmax
211, 329 nm
SMILES
CC1=CC=C(O1)C2C3=C4C(C(N(C)C(N4C)=O)=O)=C(C5=CC=CC=C5)N3C6=C(C=CC=C6)N2
InChi Code
InChI=1S/C26H22N4O3/c1-15-13-14-19(33-15)21-24-23-20(25(31)29(3)26(32)28(23)2)22(16-9-5-4-6-10-16)30(24)18-12-8-7-11-17(18)27-21/h4-14,21,27H,1-3H3
InChi Key
MNOOVRNGPIWJDI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-16275-50 |
|---|---|
| Supplier Part Number | 16275-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 931706-15-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |